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NFL Week 2 best bets: 49ers, Bills, and Saints will roll

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The NFL is back in action, and the Week 2 slate is full of games that should attract plenty of action on the betting markets.

Last week I went 5-2-1 in my ‘best bets’ picks, and I’m hoping this week can be even more profitable.

With that being said, here are my best bets heading into Week 2.

Odds courtesy of DraftKings Sportsbook as of September 18, 2020.

San Francisco 49ers (-6.5)

San Francisco may be coming off a Week 1 loss to the Arizona Cardinals, but do yourself a favor and don’t overthink this one. The 49ers are a vastly superior team here and will likely beat the Jets comfortably by double digits.

Buffalo Bills (-5.5)

I loved the Bills last week, and that trend continues this week. Yes, they have to travel down to Miami, but in all honesty, the Dolphins just aren’t on their level.

This game could be ugly (I see Buffalo holding Miami to 10-14 points), but the Bills should easily win by a touchdown or more.

Green Bay Packers (-6)

Aaron Rodgers and the Packers were dominant in Week 1, and they face a Lions team in Week 2 that has been decimated by injuries — particularly in their secondary.

At -6, there is great value in Green Bay here. This is another one you don’t want to overthink.

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Chicago Bears (-5.5)

While Mitchell Trubisky inspires zero confidence, the Bears do have a top-5 defense to fall back on. The Giants have some nice pieces, but I am expecting the Bears to stifle their young offense and win this game by a touchdown or more in a relatively low-scoring affair.

New Orleans Saints (-5.5)

The Saints travel to Las Vegas to take on the Raiders in the first game in Allegiant Stadium on Monday night. While emotions will certainly be high for Derek Carr and his teammates, I just don’t see them keeping up with Drew Brees and the Saints — even with Michael Thomas doubtful for this one.

I like the Saints by a touchdown or more.

Atlanta Falcons (+5.5)

The Falcons and Cowboys are both coming off Week 1 losses, and I expect both teams to come out firing in this matchup. I don’t necessarily like the Falcons to win outright, but I do think they’ll keep it close. Expect this game to be high-scoring (the over is in play for me also) and decided by a field goal or less on either side.

49ers/Jets under 42.5 points

To top off all of the Jets’ ongoing issues, they are also now battling the injury bug. As I mentioned above, I like the Niners by double-digits here, and I expect them to hold the Jets to 10 or fewer points.

All said, I see this game ending up somewhere in the 27-10 range in favor of San Francisco.

Buccaneers/Panthers over 47.5 points

In Week 1 the Panthers’ defense gave up 34 points to a Las Vegas Raiders offense that, quite frankly, isn’t even close to being in the same class as the Buccaneers from an overall talent perspective. Likewise, the Bucs defense also gave up 34 points to the Saints in their season opener.

Bottom line: I have the Buccaneers with a floor of 35 points in this one, and I wouldn’t be surprised to see them with a point total in the mid-40’s. The Panthers were solid on offense in Week 1, and I expect that to continue with them scoring 21 or more on Tampa Bay’s defense.

Expect this game to go well over 47.5 total points.

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